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Hard metal-induced disease: effects of metal cations in vitro on guinea pig isolated airways.

Authors
Fedan-JS
Source
Toxicol Appl Pharmacol 2001 Apr; 174(3):199-206
NIOSHTIC No.
20021728
Abstract
Inhalation of dust from hard metal (HM), a mixture of tungsten carbide, cobalt, and other metals, can cause interstitial alveolitis, fibrosis, and asthma in the workplace. Some effects of HM could occur after the metals dissolve in the lung. We examined whether chloride salts of metals in HM alloys can elicit responses or modify reactivity to methacholine (MCh) or responses to electric field stimulation (EFS) in guinea pig tracheal strips. In unstimulated strips, Co(2+), Cd(2+), and Ni(2+) evoked contractions (>3 x 10(-6) M), while Ta(5+), Zn(2+), Cr(2+), and Cr(3+) caused weak relaxations (>10(-5) M). In strips contracted with MCh (3 x 10(-7) M), Co(2+) and Ni(2+) also caused relaxation in lower concentrations while the other metals caused weak relaxation only in high concentrations (>10(-4) M). The metals were generally without effect on reactivity to MCh, except that Cd(2+) inhibited and Ni(2+) potentiated some responses. The effects of selected metals (10(-6) M; Cr(3+), Ni(2+), Cd(2+), and Co(2+)) on EFS-induced contractile and relaxant responses were examined (+/-MCh; +/-10(-6) M indomethacin (Indo), 30 min). No metal had any effect on the excitatory nonadrenergic, noncholinergic-mediated contraction phase. Cd(2+) and Ni(2+) inhibited cholinergically mediated contractions of unstimulated strips (+Indo), whereas Cr(3+) both inhibited (-MCh, -Indo) and potentiated (-Indo,+MCh; +Indo, +MCh) contractile responses. Cr(3+) was the only metal to inhibit the inhibitory nonadrenergic, noncholinergic-mediated relaxation phase (+/-MCh; -Indo). Co(2+) had no effect at all. The results suggest that smooth muscle tone and nerves in the airways could be targets of cationic metals after they dissolve in the lung.
Keywords
Inhalation-studies; Nerves; Diseases; In-vitro-studies; Laboratory-animals; Animals; Animal-studies; Airway-obstruction; Dusts; Dust-particles; Bronchial-asthma; Fibrosis; Metals; Metal-compounds; Tungsten-compounds; Chromium-compounds; Cadmium-compounds; Cobalt-compounds; Nickel-compounds; Zinc-compounds
Contact
NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
TXAPA9
CAS No.
7440-66-6; 7440-48-4; 7440-43-9; 7440-47-3; 7440-02-0
Publication Date
20010401
Document Type
Journal Article
Email Address
jsf2@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0041-008X
NIOSH Division
HELD
Source Name
Toxicology and Applied Pharmacology
State
WV
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