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Cell apoptosis induced by carcinogenic metals.

Authors
Chen-F; Vallyathan-V; Castranova-V; Shi-X
Source
Mol Cell Biochem 2001 Jun; 222(1-2):183-188
NIOSHTIC No.
20021699
Abstract
Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.
Keywords
Carcinogens; Metals; Occupational-exposure; Environmental-exposure; Toxins; Toxic-effects; Metal-compounds; Cancer; Arsenic-compounds; Chromium-compounds; Vanadium-compounds
Contact
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CODEN
MCBIB8
CAS No.
7440-38-2; 7440-62-2; 7440-47-3
Publication Date
20010601
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
WV
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