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Sensitive early indicators of hepatic and kidney damage in workers exposed to jet fuel (JP-8).

Authors
Snawder-JE; Butler-MA; Clark-JC; Knecht-EA; Krieg-EF Jr.
Source
JP8: Final Risk Assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :81-86
NIOSHTIC No.
20021453
Abstract
The study group represents a very healthy segment of the population. Sensitive measures for liver and kidney damage did not detect any adverse effects in specimens from this study group. Evidence of elevated creatinine in the mean post-shift samples of exposure category 3 was seen. However, while these values are within normal clinical ranges, they are consistent with concentrated urine indicative of mild dehydration. Because of the elevated urine creatinine levels in post-shift samples of exposure category 3, there is an apparent decrease in pre- vs. post-shift levels of Neph alpha- and pi-GST in these samples. This is an artifact of the concentrated creatinine. When levels of urinary GSTs are expressed on a per volume basis, levels remain unchanged between pre- and post-shift samples.
Keywords
Jet engine fuels; Air force personnel; Exposure; Physiology; JP-8; Jet propellant type 8; Kidney function; Liver function; Liver enzymes; Liver; Kidneys; Biomarkers
Publication Date
20010801
Document Type
Book or book chapter
Editors
Kendall-RK; Smith-E
Fiscal Year
2001
NTIS Accession No.
ADA-443114
NTIS Price
NIOSH Division
DART
Source Name
JP8: Final Risk Assessment
State
OH; TX
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