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A model for controlling and quantifying volitional muscle performance of rat plantar flexors in vivo.

Authors
Shastri-V; Wirth-O; Cutlip-RG
Source
Med Sci Sports Exerc 2001 May; 33(5)(Suppl 1):S295
NIOSHTIC No.
20021445
Abstract
An in vivo animal model was developed to study the effects of volitional, eccentric, concentric, and isometric muscle actions and varying work-rest cycles on muscle performance, behavior, and histological and biochemical response. Using a custom-designed apparatus that was attached to a standard operant chamber, rats were operantly conditioned with food rewards to perform a voluntary lifting task to generate controlled movement of the plantar flexors. An opening in the front panel of the operant chamber allowed the rat to enter a Plexiglass tube that was mounted vertically to restrict the movement of the rat. A load cell was embedded in a platform at the bottom of the tube to measure they dynamic force exerted by the plantar flexors. Inside the tube, a neck ring was supported by a yoke that moved along two vertical shafts via linear bearings. A displacement transducer (LVDT) was attached to the weight pans to measure the range of motion on the lift, and allowed determinations of velocity and acceleration of the lifting motion.
Keywords
In-vivo-studies; Muscles; Animal-studies; Laboratory-animals; Biochemical-tests; Acceleration
CODEN
MSPEDA
Publication Date
20010501
Document Type
Abstract
Editors
Raven-PB
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0195-9131
NIOSH Division
HELD
Priority Area
Research Tools and Approaches
Source Name
Medicine and Science in Sports and Exercise
State
WV
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