Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Immunotoxicology: effects of, and response to, drugs and chemicals.

Authors
Dean-JH; House-RV; Luster-MI
Source
Principles and Methods of Toxicology, 4th Edition. AW Hayes, ed., Philadelphia, Pennsylvania: Taylor & Francis, 2001 Jan; :1415-1450
Link
NIOSHTIC No.
20021287
Abstract
The immune system is a complex, multi-cellular organ system consisting of granulocytes, macrophages, lymphocytes, and dentritic cells with various functions and phenotypic characteristics, as well as various soluble mediators. These cells of hemopoietic origin are found in the peripheral blood, lymphatic fluid, and organized lymphoid tissues, including bone marrow, spleen, thymus, lymph nodes, tonsils, and mucosa-associated lymphoid tissue. The immune system is in a constant state of self-renewal involving cell proliferation , differentiation, and maturation. It exists to defend the body against invasion by infectious and opportunistic microorganisms, and spontaneously arising neoplasms. This network of cells and soluble factors is highly regulated and interdependent, must discriminate self from non-self, and can react to non-self with many different (pleiotropic) defensive responses (81).
Keywords
Immunotoxins; Immune-system; Lymphocytes; Lymphatic-system; Bone-marrow; Spleen-disorders; Lymph-nodes; Cell-differentiation; Microorganisms; Infectious-diseases; Neoplasms
Publication Date
20010101
Document Type
Book or book chapter
Editors
Hayes-AW
Fiscal Year
2001
NTIS Accession No.
NTIS Price
ISBN No.
1560328142
NIOSH Division
HELD
Source Name
Principles and Methods of Toxicology, 4th Edition
State
OH; PA
TOP