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Uniformity test of bias when the reference value contains experiment error.

Authors
Song-R; Kennedy-E; Bartley-D
Source
Anal Chem 2001 Jan; 73(2):310-314
NIOSHTIC No.
20021241
Abstract
The uniformity test of biases for analytical methods must address uncertainties in the reference method. If the uncertainty associated with the estimates of true values is significant but ignored in the test of bias equality, the type I error can exceed the prespecified error rate. In general, when biases at each concentration level are confounded with a random component (confounding bias), the usual test of bias equality tests the uniformity of the combined bias, rather than the uniformity of fixed bias-the bias without the random component. Based on a confounding model that takes both the fixed and the confounding biases into account, the actual type I error rate of the uniformity test can be calculated. To eliminate the impact of confounding bias on the uniformity test of fixed biases, a new F'-test is proposed. The new F'-test is simply adding a correction factor to the conventional F-test. The correction factor is directly related to the uncertainty associated with the estimates of true values. A simulation study is conducted to show that the proposed test can bring the type I error rate down to the prespecified level. Data from two aldehyde methods are used to demonstrate how the proposed F'-test works. Recommendations on optimal sample allocation are also provided.
Keywords
Analytical-methods; Data-processing; Aldehydes; Sampling; Environmental-factors
CODEN
ANCHAM
Publication Date
20010115
Document Type
Journal Article
Email Address
RSong@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0003-2700
NIOSH Division
DART
Priority Area
Research Tools and Approaches; Other Occupational Concerns
Source Name
Analytical Chemistry
State
OH
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