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Genetic engineering and molecular technology.

Authors
Bolon-BD; Galbreath-E; Sargent-L; Weiss-J
Source
The Laboratory Rat. Krinke GJ, Bullock G, Bunton T, eds., London: Academic Press, 2000 Jun; :603-633
Link
NIOSHTIC No.
20020895
Abstract
Scientists have been performing genetic manipula­tions and analyses since Mendel first reported the heritable nature of physical characteristics in pea plants in 1865. With respect to rats, experimental biologists who crossbred rat strains for a variety of traits (Chapter 1) were occasionally rewarded by the advent of an unexpected functional or structUral phenotype. Such serendipitously acquired mutant lines, most of which result froT a spontaneous mutation to a single gene, were often expanded and characterized to serve as animal models of human diseases. However, a large-scale random breeding program to produce new lines with novel mutations would be very costly in rodents, even if combined with treatments that accelerate the muta­tion rate (e.g. Kasarkis et al., 1998). Furthermore, random breeding schemes and mutagenic agents cannot be employed effectively to produce defects in specific genes of interest.
Keywords
Genetics; Genetic-factors; Genetic-engineering; Molecular-biology; Laboratory-animals; Animals; Animal-studies; Genes
Publication Date
20000615
Document Type
Book or book chapter
Editors
Krinke-GJ; Bullock-G; Bunton-T
Fiscal Year
2000
NTIS Accession No.
NTIS Price
ISBN No.
012426400X
NIOSH Division
HELD
Source Name
The Laboratory Rat
State
WV
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