Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Organochlorine exposures and breast cancer risk in New York City women.

Authors
Wolff-MS; Berkowitz-GS; Brower-S; Senie-R; Bleiweiss-IJ; Tartter-P; Pace-B; Roy-N; Wallenstein-S; Weston-A
Source
Environ Res 2000 Oct; 84(2):151-161
NIOSHTIC No.
20020861
Abstract
A hospital-based case-control study of breast cancer risk related to organochlorine (OC) exposure was conducted in a multiethnic setting in New York City. We enrolled 175 breast cancer patients and 355 control patients. The overall racial/ethnic distribution was 57% Caucasian, 21% Hispanic, 22% African-American; cases and controls were frequency-matched by age and race/ethnicity. Tumor markers (estrogen and progesterone receptors, p53, erbB-2) were assessed and organochlorines (DDE, DDT, trans-nonachlor, and higher (HPCB) and lower (LPCB) chlorinated biphenyls) were measured in blood serum. Tumors among minority women were of slightly higher stage than among Caucasians, but tumor markers were similar across the racial/ethnic groups. DDE levels were highest among African-American and Hispanic women; DDT was highest among Hispanics; HPCBs were highest among African-Americans; LPCBs were lowest among Hispanics; and trans-nonachlor was highest among African-Americans. However, OC levels were not associated with risk for breast cancer, nor did OCs differ with respect to tumor stage or tumor markers. Higher DDE levels were associated with increasing body mass index (BMI), but with decreasing level of education, frequency of nulliparity, and frequency of family history of breast cancer. HPCB levels decreased with BMI and were not correlated with breast cancer risk factors. These relationships can be attributed to historical patterns of exposure and to metabolic differences in OCs related to BMI.
Keywords
Organo-chlorine-compounds; Breast-cancer; Cancer; Demographic-characteristics; Sex-factors; Case-studies; Exposure-levels; Exposure-assessment; Risk-analysis; Risk-factors; Age-factors; Racial-factors; Tumors
CODEN
ENVRAL
Publication Date
20001001
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0013-9351
NIOSH Division
HELD
Source Name
Environmental Research
State
WV; NY
TOP