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Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?

Authors
Simeonova-PP; Luster-MI
Source
J Environ Pathol Toxicol Oncol 2000 Jul-Sep; 19(3):281-286
NIOSHTIC No.
20020811
Abstract
Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic carcinogenesis have not been established. Arsenic does not act through classic genotoxic and mutagenic mechanisms, as do other metals such as cadmium or chromium. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth.
Keywords
Arsenic-compounds; Arsenates; Carcinogenesis; Carcinogenicity; Carcinogens; Occupational-exposure; Environmental-exposure; Skin-cancer; Respiratory-system-disorders; Bladder-cancer; Risk-factors; Risk-analysis; Cell-growth; Genes
Contact
Petia P. Simeonova, NIOSH, HELD, TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888
CODEN
JEPOEC
CAS No.
7440-38-2
Publication Date
20000701
Document Type
Journal Article
Email Address
phs9@cdc.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0731-8898
NIOSH Division
HELD
Source Name
Journal of Environmental Pathology, Toxicology, and Oncology
State
WV
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