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Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China.

Authors
Roth-MJ; Dawsey-SM; Wang-GQ; Tangrea-JA; Zhou-B; Ratnasinghe-D; Woodson-KG; Olivero-OA; Poirier-MC; Frye-BL; Taylor-PR; Weston-A
Source
Cancer Lett 2000 Aug; 156(1):73-81
NIOSHTIC No.
20020798
Abstract
Individuals with specific phase I and phase II enzyme polymorphisms may be at increased risk for squamous cell carcinoma of the esophagus. However, to our knowledge there has been only one previous report that evaluates a potential role for these polymorphisms in increasing risk for preneoplastic squamous lesions of the esophagus. To explore this further, we examined polymorphisms in CYP1A1, CYP2E1, GSTM1 and GSTT1, both independently and in combination, for potential associations with the risk of biopsy-proven squamous dysplasia of the esophagus in asymptomatic adults from Linxian, a high risk region in China. Cases consisted of 56 individuals from an esophageal cancer screening study with an endoscopic biopsy diagnosis of mild or moderate squamous dysplasia. Each case was matched on age (+/- 1 year) and gender to a control. Controls were defined as screening study participants with an endoscopic biopsy diagnosis of normal mucosa or esophagitis. DNA was extracted from frozen cell samples obtained by cytologic balloon examination and genotyped using standard methods. Individuals who were GSTM1 null (homozygous for GSTM1*0) were found to have a tendency for an increased risk of esophageal squamous dysplasia (odds ratio=2.6, 95% CI, 0.9-7.4). No excess risks were observed for inheritance of other putative at risk genotypes CYP1A1*2B, CYP2E1*6 or GSTT1*0. The risk associated with the inheritance of combined genotypes was not significantly different than the risk estimates from the univariate analysis. These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian.
Keywords
Demographic-characteristics; Enzymes; Risk-analysis; Risk-factors; Carcinomas; Cancer; Age-factors; Sex-factors; Environmental-exposure; Carcinogens; Polycyclic-aromatic-hydrocarbons; Epidemiology; Statistical-analysis
Contact
Suite 321, 6006 Executive Boulevard MSC 7058, Bethesda, Maryland 20892-7058, USA
CODEN
CALEDQ
Publication Date
20000801
Document Type
Journal Article
Email Address
mr166@nih.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0304-3835
NIOSH Division
HELD
Source Name
Cancer Letters
State
WV; MD
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