Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Dermal absorption and tissue disposition of 3,3',4,4'-tetrachlorobiphenyl (TCB) in an ex-vivo pig model: assessing the impact of dermal exposure variables.

Authors
Qiao-GL; Riviere-JE
Source
Int J Occup Environ Health 2000 Apr-Jun; 6(2):127-137
NIOSHTIC No.
20020787
Abstract
TCB is one of the dioxin-like polychlorinated biphenyls (PCBs). This research was designed to help assess the risk of occupational and environmental TCB exposure. To evaluate exposure variables' effects on dermal absorption and cutaneous disposition, 14C-TCB (40 microg/cm(2)) in acetone, methylene chloride, a water-acetone mixture, and a soil-based mixture were applied in an ex-vivo pig-skin-flap model (n = 4-5/treatment). Dermal absorption (0.11-0.66%, 8 hr) and penetration (1.14-2.48%) varied according to exposure conditions. Acetone and methylene chloride vehicles differed in absorption profiles and skin penetration patterns but were similar in absorption amounts. Adding water to the acetone did not change absorption but did alter the penetration pattern. The non-occluded soil-based mixture showed more absorption than did the liquid vehicles (p<0.05), but occlusion significantly (p<0.05) decreased that absorption (0.66->0.29%, 8 hr) and penetration (2.48->1.11%). In conclusion, dermal absorption data from liquid-organic or aqueousorganic mixtures may underestimate the risk of exposure to TCB-contaminated soil.
Keywords
Polychlorinated-biphenyls; Biphenyls; Skin-absorption; Skin-exposure; Pharmacodynamics
Contact
NIOSH, Centers for Disease Control, Morgantown, WV 26505-2888
CODEN
IOEHFU
CAS No.
32598-13-3
Publication Date
20000401
Document Type
Journal Article
Email Address
gaq1@cdc.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1077-3525
NIOSH Division
HELD
Source Name
International Journal of Occupational and Environmental Health
State
WV
TOP