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Couriers of asthma: antigenic proteins in natural rubber latex.

Authors
Petsonk-EL
Source
Occup Med: State of the Art Rev 2000 Apr; 15(2):421-430
Link
NIOSHTIC No.
20020780
Abstract
Natural rubber latex (NRL) is a milky, white liquid containing the polymer cis-1,4-polyisoprene, derived from the laticifer cells of the rubber tree, Hevea brasiliensis. Reports of allergic reactions to NRL, ranging in severity from skin rashes to anaphylaxis and death, have been increasing. High rates of latex allergy are seen in children with spina bifida. Healthcare workers, especially those who frequently use powdered latex medical gloves, can develop NRL allergy and asthma, often resulting in considerable disability. Atopy and, possibly, pre-existing dermatitis predispose to sensitization and allergic symptoms. NRL protein antigens are found in many NRL products and also have been shown to bind to cornstarch glove-donning powders. Of the approximately 240 polypeptides in NRL, nearly 60 are antigenic, and nine have been identified and registered (Hev b 1&ndash9). Many natural latex antigens share epitopes with structural proteins and enzymes from other plant species. Current knowledge indicates that proposed reductions in total glove protein and limitations on the use of powder on NRL gloves are likely to result in a decline in the prevalence and severity of NRL allergies among healthcare workers.
Keywords
Bronchial-asthma; Antigens; Rubber-manufacturing-industry; Medical-equipment; Dermatitis; Hypersensitivity; Skin-disorders; Skin-infections; Skin-irritants; Skin-lesions; Exposure-levels; Allergic-dermatitis; Allergic-reactions; Allergies
Contact
Edward L. Petsonk, MD, National Institute for Occupational Safety and Health, Division or Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888
CODEN
SAOME4
Publication Date
20000401
Document Type
Journal Article
Editors
Banks-DE; Wang-ML
Fiscal Year
2000
NTIS Accession No.
NTIS Price
ISBN No.
9781560533269
Issue of Publication
2
ISSN
0885-114X
NIOSH Division
DRDS
Source Name
Occupational Medicine: State of the Art Reviews. Occupational Asthma
State
WV
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