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Expression of fos-related antigen-2 in rat hippocampus after middle cerebral arterial occlusion.

Authors
Pennypacker-KR; Eidizadeh-S; Kassed-CA; O'Callaghan-JP; Sanberg-PR; Willing-AE
Source
Neurosci Lett 2000 Jul; 289(1):1-4
NIOSHTIC No.
20020776
Abstract
AP-1 transcription factors have been shown to be induced in the brain after ischemic injury. However, their roles in neuronal survival or death have yet to be defined. Here, we report the discovery of elevated nuclear levels of fos-related antigen-2 (FRA-2) in the nuclei of hippocampal neurons seven days after middle cerebral artery occlusion (MCAO). Expression of FRA-2 and AP-1 DNA binding activity is elevated in hippocampi ipsilateral as well as contralateral to MCAO. Using Fluoro-Jade staining as a marker of neurodegeneration, FRA-2 was not found to be expressed in degenerating neurons. Thus, FRA-2 is expressed in neurons that survive ischemic insult suggesting a role for this transcription factor in neuronal adaptation to the post-injury state.
Keywords
Laboratory-animals; Animal-studies; Animals; Antigens; Brain-damage; Brain-disorders; Injuries; Central-nervous-system-disorders; Central-nervous-system
Contact
Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 9, Tampa, FL 33612, USA
CODEN
NELED5
Publication Date
20000728
Document Type
Journal Article
Email Address
kpennypa@hsc.usf.edu
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0304-3940
NIOSH Division
HELD
Source Name
Neuroscience Letters
State
WV; FL
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