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Prioritization of NTP reproductive toxicants for field studies.

Authors
Moorman-WJ; Ahlers-HW; Chapin-RE; Daston-GP; Foster-PMD; Kavlock-RJ; Morawetz-JS; Schnorr-TM; Schrader-SM
Source
Reprod Toxicol 2000 Jul-Aug; 14(4):293-301
NIOSHTIC No.
20020760
Abstract
Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among health scientists, unions, and industry can serve to identify populations exposed to potential hazards and develop strategies to evaluate and apply appropriate controls. This report describes a systematic method for prioritizing chemicals that may need human reproductive health field studies. Rodent reproductive toxicants identified from the National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were prioritized on the basis of potency of toxic effect and population at risk. This model for prioritization links NTP findings with data from the National Occupational Exposure Survey (NOES) and the Hazardous Substance Data Base (HSDB) or the High Production Volume Chemical Database (HPVC) to prioritize chemicals for their potential impact on worker populations. The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N,N-dimethylformamide.
Keywords
Reproductive-system; Reproductive-hazards; Reproduction; Reproductive-effects; Reproductive-system-disorders; Chemical-analysis
Contact
National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy, Cincinnati OH, 45226, USA
CODEN
REPTED
Publication Date
20000701
Document Type
Journal Article
Email Address
wmj2@cdc.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0890-6238
NIOSH Division
DART; EID; DSHEFS
Source Name
Reproductive Toxicology
State
OH
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