Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice.

Authors
Mani-SK; Feinberg-AA; O'Callaghan-JP; Snyder-GL; Allen-PB; Dash-PK; Moore-AN; Mitchell-AJ; Bibb-J; Greengard-P; O'Malley-BW
Source
Science 2000 Feb; 287(5455):1053-1056
NIOSHTIC No.
20020746
Abstract
DARPP-32, a dopamine- and adenosine 3',5'-monophosphate (cAMP)-regulated phosphoprotein (32 kilodaltons in size), is an obligate intermediate in progesterone (P)-facilitated sexual receptivity in female rats and mice. The facilitative effect of P on sexual receptivity in female rats was blocked by antisense oligonucleotides to DARPP-32. Homozygous mice carrying a null mutation for the DARPP-32 gene exhibited minimal levels of P-facilitated sexual receptivity when compared to their wild-type littermates. P significantly increased hypothalamic cAMP levels and cAMP-dependent protein kinase activity. These increases were not inhibited by a D1 subclass dopamine receptor antagonist. P also enhanced phosphorylation of DARPP-32 on threonine 34 in the hypothalamus of mice. DARPP-32 activation is thus an obligatory step in progestin receptor regulation of sexual receptivity in rats and mice.
Keywords
Laboratory-animals; Animals; Animal-studies; Genetic-factors; Genes; Gene-mutation; Reproductive-effects; Reproductive-system-disorders
CODEN
SCIEAS
Publication Date
20000211
Document Type
Journal Article
Email Address
smani@bcm.tmc.edu
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
5455
ISSN
0036-8075
NIOSH Division
HELD
Source Name
Science
State
WV; TX; NY; CA
TOP