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The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.

Authors
Luster-MI; Simeonova-PP; Gallucci-RM; Bruccoleri-A; Blazka-ME; Yucesoy-B; Matheson-JM
Source
Ann NY Acad Sci 2000 Sep; 919:214-220
NIOSHTIC No.
20020738
Abstract
Only recently have toxicologists come to understand the role of inflammation, and TNFalpha specifically, in classical toxicological processes. This relationship appears fairly complex, as inflammation and proliferation may well be only one facet of a time- and dose-dependent continuum of toxicological and repair processes. Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use. Their effectiveness in controlling environmental or occupational diseases has yet to be established.
Keywords
Hepatotoxicity; Hepatotoxins; Hepatocytes; Toxicology; Occupational-diseases; Environmental-hazards; Environmental-health
CODEN
ANYAA9
Publication Date
20000901
Document Type
Journal Article
Email Address
myl6@cdc.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
ISBN No.
9781573312653
ISSN
0077-8923
NIOSH Division
HELD
Source Name
Annals of the New York Academy of Sciences
State
WV; NJ
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