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A laboratory comparison of two media for use in the assessment of dermal exposure to pesticides.

Authors
Lorberau-CD; Pride-JL
Source
Appl Occup Environ Hyg 2000 Dec; 15(12):946-950
NIOSHTIC No.
20020736
Abstract
In a laboratory study, gauze pads and Empore1 filters were compared for their ability to assess the dermal exposure of two insecticides (chlorpyrifos and diazinon) and five herbicides (atrazine, alachlor, metolachlor, cyanazine, and 2,4-D ethylhexyl ester). The analytes, when analyzed by gas chromatography with flame ionization detection, were found to have a linear dynamic range to at least 250 micro g/mL. While a number of different solvents were examined for the desorption of the analytes, methanol was found to be the best solvent for the recovery of all the analytes from 16-ply gauze pads, while 20 percent ethyl acetate in hexane was the preferred solvent for the styrene divinylbenzeneimpregnated Empore filters. Limits of detection (LODs) for the analytes were comparable for both media. For Empore filters, the LODs were 50 micro g/sample for atrazine, alachlor, chlorpyrifos, diazinon, and 2,4-D ethylhexy ester, with 30 miocro g/ sample for metolachlor, and 80 micro g/sample for cyanazine. For gauze pads, the LODs were 40 micro g/sample for metolachlor, 50 micro g/sample for alachlor, diazinon, and 2,4-D ethylhexy ester, 60 micro g/sample for atrazine and chlorpyrifos, and 80 micro g/sample for cyanazine. Both gauze pads and Empore filters gave quantitative recovery for all analytes except chlorpyrifos and 2,4-D ethylhexyl ester under ambient conditions (18oC, 70% relative humidity) for up to 30 days; these analytes required refrigeration for that period to reach over 90 percent recovery. To assess the effect of environmental conditions on the recovery of the analytes, samples of each media were spiked at about 125 micro g per analyte/sample (except cyanazine which was spiked at 190 micro g) and challenged for 8 hr under high (80%) and low (20%) humidity and high (40 degrees C) and low (5 degrees C) temperature conditions in an environmental chamber. While the Empore samples gave quantitative recovery after being challenged, recovery from the gauze pads was affected by environmental conditions, especially high temperature. Recovery from gauze pads was below 30 percent for some analytes under high temperature/high humidity conditions.
Keywords
Insecticides; Herbicides; Pesticides; Sampling; Sampling-methods; Sampling-equipment; Analytical-methods; Analytical-chemistry; Analytical-processes; Skin-exposure
CODEN
AOEHE9
CAS No.
2921-88-2; 333-41-5; 1912-24-9; 15972-60-8; 51218-45-2; 21725-46-2; 94-75-7
Publication Date
20001201
Document Type
Journal Article
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1047-322X
NIOSH Division
DPSE
Source Name
Applied Occupational and Environmental Hygiene
State
AL; OH
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