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Diesel exhaust exposure and lung cancer: adjustment for the effect of smoking in a retrospective cohort study.

Authors
Larkin-EK; Smith-TJ; Stayner-LT; Rosner-B; Speizer-FE; Garshick-E
Source
Am J Ind Med 2000 Oct; 38(4):399-409
NIOSHTIC No.
20020727
Abstract
The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 living workers from an active railroad in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 (95% CI = 1.14-2.20) for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44 (1.01-2.05). After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure.
Keywords
Diesel-exhausts; Diesel-emissions; Lung-cancer; Lung-disorders; Lung-function; Cigarette-smoking; Railroad-industry; Railroads; Pulmonary-system-disorders; Respiratory-system-disorders; Statistical-analysis; Demographic-characteristics; Author Keywords: confounding; diesel exhaust; lung cancer; railroad workers; smoking
Contact
Eric Garshick, MOH Medical and Research Service, VA Boston Health Care Systems, 1400 UFW Parkway, Boston, MA 02132
CODEN
AJIMD8
Publication Date
20001001
Document Type
Journal Article
Email Address
eric.garshick@med.va.gov
Funding Amount
279815
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-CCR-115818
Issue of Publication
4
ISSN
0271-3586
NIOSH Division
EID
Priority Area
Work Environment and Workforce: Mixed Exposures
Source Name
American Journal of Industrial Medicine
State
OH; MA
Performing Organization
Harvard Medical School, Boston, Massachusetts
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