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Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis.

Authors
Kagan-VE; Fabisiak-JP; Shvedova-AA; Tyurina-YY; Tyurin-VA; Schor-NF; Kawai-K
Source
FEBS Lett 2000 Jul; 477(1-2):1-7
NIOSHTIC No.
20020712
Abstract
Active maintenance of membrane phospholipid asymmetry is universal in normal cell membranes and its disruption with subsequent externalization of phosphatidylserine is a hallmark of apoptosis. Externalized phosphatidylserine appears to serve as an important signal for targeting recognition and elimination of apoptotic cells by macrophages, however, the molecular mechanisms responsible for phosphatidylserine translocation during apoptosis remain unresolved. Studies have focused on the function of aminophospholipid translocase and phospholipid scramblase as mediators of this process. Here we present evidence that unique oxidative events, represented by selective oxidation of phosphatidylserine, occur during apoptosis that could promote phosphatidylserine externalization. We speculate that selective phosphatidylserine oxidation could affect phosphatidylserine recognition by aminophospholipid translocase and/or directly result in enzyme inhibition. The potential interactions between the anionic phospholipid phosphatidylserine and the redox-active cationic protein effector of apoptosis, cytochrome c, are presented as a potential mechanism to account for selective oxidation of phosphatidylserine during apoptosis. Thus, cytochrome c-mediated phosphatidylserine oxidation may represent an important component of the apoptotic pathway.
Keywords
Phospholipids; Oxidation; Oxidative-processes; Oxidative-phosphorylation; Enzymes
Contact
Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, RIDC Park, Pittsburgh, PA 15238, USA
CODEN
FEBLAL
Publication Date
20000714
Document Type
Journal Article
Email Address
kagan@pitt.edu
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0014-5793
NIOSH Division
HELD
Source Name
Federation of European Biochemical Societies Letters
State
WV; PA
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