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Lung responses to hypothyroidism, hyperthyroidism, and lipopolysaccharide challenge in rats.

Authors
Huffman-LJ; Judy-DJ; Rao-KMK; Frazer-DG; Goldsmith-WT
Source
J Toxicol Environ Health, A 2000 Dec; 61(7):623-639
NIOSHTIC No.
20020705
Abstract
The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on some factors involved in lung injury under basal conditions (air exposure) and during an inflammatory response induced by inhalation exposure to lipopolysaccharide (LPS; 100 microg/ml; 3 h) in adult rats. Thyroid status was altered by thyroidectomy or thyroxine injections for 15 d. Hyperthyroidism alone caused a greater degree of lung cell damage, an increase in the permeability of the alveolar-capillary barrier, a rise in the total number of phagocytic cells obtained by bronchoalveolar lavage (BAL), and enhanced nitric oxide (NO) release by phagocytic cells relative to that in euthyroid control animals. Hypothyroidism alone was associated with opposite effects. Exposure of animals to LPS produced inflammatory responses, which included significant increases in lung cell damage, permeability of the alveolar-capillary barrier, number of phagocytic cells obtained by BAL, and NO production by the phagocytic cells. In general, hyperthyroidism enhanced the effects of LPS, while hypothyroidism reduced LPS-induced responses. These results suggest that thyroid status alone can affect some of the factors involved in lung injury and also modulate some of the inflammatory effects of LPS. Hyperthyroidism tends to enhance lung injury, while hypothyroidism seems to reduce lung injury.
Keywords
Lung-disorders; Pulmonary-system-disorders; Respiratory-system-disorders; Inhalation-studies; Exposure-levels; Laboratory-animals; Animals; Animal-studies; Phagocytic-activity; Phagocytes; Thyroid-gland-disorders; Endocrine-system-disorders; Endocrinology
Contact
Linda Huffman, PhD, M/S 2015, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JTEHD6
CAS No.
10102-43-9
Publication Date
20001215
Document Type
Journal Article
Email Address
ljh3@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1528-7394
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
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