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Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge.

Authors
Flint-MS; Valosen-JM; Johnson-EA; Miller-DB; Tinkle-SS
Source
J Neuroimmunol 2001 Feb; 113(1):72-80
NIOSHTIC No.
20020672
Abstract
BALB/c mice were sensitized and challenged on the skin with the contact sensitizer, dinitroflourobenzene. Acute restraint applied before sensitization diminished, whereas restraint administered before challenge enhanced, chemical-induced ear swelling and leukocytic infiltration in the dermis. Administration of RU486, a glucocorticoid receptor antagonist, partially reversed restraint modulation of the ear swelling response in both restraint paradigms. Restraint did not modulate significantly the concentration of TNF-alpha and IL-1 beta in ear tissue homogenates. These data show that acute restraint modulates cutaneous sensitization differently than challenge, but the changes are not reflected in TNF-alpha or IL-l beta production.
Keywords
Skin; Sensitization; Leukocytes; Immune-system; Immune-reaction; Allergic-dermatitis; Contact-dermatitis; Laboratory-animals; Animals; Animal-studies
CODEN
JNRIDW
Publication Date
20010201
Document Type
Journal Article
Email Address
sft3@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
ISSN
0165-5728
NIOSH Division
HELD
Source Name
Journal of Neuroimmunology
State
WV
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