Susceptibility to genetic damage from butadiene.
NIOSH 1995 Jan; :1-5
Exposure to butadiene has been assessed with 8-hour time weighted average personal sampling as well as urine collection and metabolite determination. Significant data have been collected by questionnaire and blood has also been collected. Early analysis of the data reveals baseline cytogenetic changes in the exposed group to be unrelated to time-weighted average measurements of exposure. Urine was collected and there is no relationship between induced cytogenetic damage and urinary measures of exposure to butadiene. However, examination of high SCE frequency cells reveals that there is some relationship between length in the trade and high frequency SCE cells present in workers. Also, one individual who had previously been noted to have a very high hprt mutant fraction was also sensitive to diepoxybutane in vitro. Thus our work indicates that acute exposure to 1,3-butadiene was not associated with induction of chromosomal abnormalities. However, tenure in the trade was associated with production of high SCE frequency cells.
Gene-mutation; Butadienes; Cancer; Carcinogens; Humans
Final Grant Report
National Institute for Occupational Safety and Health
Harvard University, School of Public Health, Occupational Health Program, Boston, Massachusetts