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Autoimmunity and risk assessment.

Authors
Luster-MI; Simeonova-PP; Gallucci-R; Matheson-J
Source
Environ Health Perspect 1999 Oct; 107(Suppl 5):679-680
NIOSHTIC No.
20000961
Abstract
Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development in order to improve risk assessment. The estimation of risk (i.e., the probability of a deleterious effect resulting from exposure) involves both the qualitative evaluation of whether a hazard exists and the quantitative evaluation for determining an acceptable level of exposure in humans. Unless adequate human data are available, which is uncommon, this is based on animal studies. Although animal models exist to study autoimmune processes, these models do not readily lend themselves to interpretation in the risk assessment process due, for the most part, to the complexity of autoimmune disease(s), as they are multifactorial and exhibit genetic heterogeneity in humans. To improve the risk assessment process, researchers must develop and validate animal models that not only incorporate mechanistic information into the assessment process but also allow for consideration of potent genetic, physiologic, and environmental influences.
Keywords
Immune-system-disorders; Environmental-hazards; Animal-models; Autoimmune-diseases; Chemical-screening; Drug-screening; Author Keywords: autoimmunity tests; immunotoxicology evaluation; immunotoxicology methods; risk assessment; xenobiotic-induced autoimmunity
Contact
M.I. Luster, Toxicology and Molecular Biology Branch Health Effects Laboratory Division NIOSH 1095 Willowdale Rd Morgantown, WV 26505
CODEN
EVHPAZ
Publication Date
19991001
Document Type
Journal Article
Email Address
myl6@cdc.gov
Fiscal Year
2000
NTIS Accession No.
NTIS Price
ISSN
0091-6765
NIOSH Division
HELD
Source Name
Environmental Health Perspectives
State
WV
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