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Acute response of rats to intratracheal instillation of airborne dust collected at a nylon flocking plant.

Authors
Castranova-V; Porter-Dale; Hubbs-A; Goldsmith-T; Whitmer-M; Robinson-VA; Schwegler-Berry-D; Battelli-L; Washko-R; Burkhart-J; Piacitelli-C; Mercer-RR; Scabilloni-J; Jones-W
Source
1999 Proceedings Beltwide Cotton Conferences, January 3 - 7, Orlando, FL. Memphis, TN: National Cotton Council of America, 1999 Jan; 1:164-166
NIOSHTIC No.
20000919
Abstract
Recently several cases of lymphocytic bronchiolitis have been identified in workers at a nylon flocking plant. The objective of this investigation was to characterize the acute pulmonary reaction to exposure to airborne thoracic/respirable dust collected from this factory and to identify a component of the dust which may cause interstitial lung disease. Rats were intratracheally instilled with 2.56 mg of dust and pulmonary reactions monitored 1 day post-exposure. The acute reactions included: increased breathing rate, PMN infiltration, activation of macrophages, and an elevation of the albumin levels of the lavage fluid. These acute reactions dissipated at 29 days post-exposure. They were not associated with endotoxin or other water extractable components but were related to nylon shreds which were small enough to reach the alveolar region of the lung. The data indicate that nylon shreds can be generated during cutting of large nylon fibers and that this material can enter the lungs and result in inflammation and possible disease.
Keywords
Fibrous-bodies; Fibrous-dusts; Synthetic-fibers; Pulmonary-system-disorders; Occupational-health;
Publication Date
19990107
Document Type
Conference/Symposia Proceedings
Editors
Dugger-P; Richter-D
Fiscal Year
1999
NTIS Accession No.
NTIS Price
ISSN
1059-2644
NIOSH Division
HELD; DRDS
Source Name
1999 Proceedings Beltwide Cotton Conferences, January 3 - 7, Orlando, FL
State
WV; FL
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