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Screening of priority chemicals for potential reproductive hazard.

Authors
Booth-GM; William-BS; Carter-MW
Source
NIOSH 1983 Apr; :1-104
Link
NIOSHTIC No.
20000714
Abstract
The objective of this work was to determine the effect of nine chemicals on selected reproductive parameters in pregnant white mice. The nine chemicals were diethylene glycol diethyl ether, ethylenethiourea, sodium selenite, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, p-nitrophenol, dimethyl phthalate, and naphthalene. The study was divided into two parts: (1) determination of a maximum tolerated dose (mtd) based on adult mortality and weight loss, and (2) a reproductive study in which the mtd dose was administered to pregnant spf cd-1 mice. Both the mtd and reproductive portions of the investigation were completed in blocks of three chemicals each or a total of three blocks for the nine compounds.
Keywords
Hazardous-materials; Exposure; Maximum-permissible-exposure; Oxygen-organic-compounds; Reproductive-effects
CAS No.
91-20-3; 10102-18-8; 112-36-7; 111-96-6; 96-45-7; 10102-18-8; 110-71-4; 112-49-2; 131-11-3; 100-02-7
Publication Date
19830401
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1983
NTIS Accession No.
PB83-213017
NTIS Price
A06
Identifying No.
Contract-210-81-6012
NIOSH Division
DBBS
Priority Area
Reproductive-system-disorders
Source Name
National Institute for Occupational Safety and Health
State
OH; UT
Performing Organization
Mesa Corporation, Orem, Utah
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