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Chronic inhalation toxicology study in monkeys and rats exposed to fibrous glass, volume 2, appendices.

Authors
Mitchell-RI; Reif-RB; Mosberg-AT; Thake-DC; Connell-MM
Source
NIOSH 1982 Oct; :1-542
Link
NIOSHTIC No.
20000713
Abstract
Data accompanying a chronic toxicity study of fiber glass in monkeys and rats is presented. The protocol and standard operating procedures of the project are given. The methodology for determining clinical chemistry and hematology parameters was presented. Daily concentrations of fiber glass concentrations in the exposure chamber are tabulated. Data used in determining the precision of light, medium, and heavy filter weights is noted. Inertial characteristics of fibers are discussed. Mean weekly body weights of the experimental animals are tabulated. Data analyses of the survival of the experimental animals are given. Coded and tabulated pathology reports for each experimental animal are presented. Particle size distribution data of glass fibers determined from filter samples in the exposure chambers are provided. Procedures for determining the size characteristics of glass fibers deposited in monkey and rat lungs are noted. Three dimensional plots of glass fiber particle size distributions in monkey and rat lungs are presented. Calculated values of the lung burden of glass fibers in rats and monkeys are listed.
Keywords
Fibrous-glass; Respiratory-system-disorders; Toxicology; Fiber-deposition; Dermatitis
Publication Date
19821025
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1983
NTIS Accession No.
PB85-222214
NTIS Price
A24
Identifying No.
Contract-210-78-0037
NIOSH Division
DBBS
Priority Area
Pulmonary-system-disorders
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Battelle Columbus Labs., Columbus, OH
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