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Criteria for a recommended standard: occupational exposure to dibromochloropropane (DBCP).

Authors
NIOSH
Source
NIOSH 1978 Jan; :1-14
NIOSHTIC No.
20000341
Abstract
The possible effects on the health of employees chronically exposed to DBCP may include sterility, diminished renal function, and degeneration and cirrhosis of the liver. In addition, ingestion of daily doses of DBCP by mice and rats has been found to result in the appearance of gastric cancers in both sexes of both species and in mammary cancers in female rats. Although an increased risk for cancer has not been seen with inhalation exposures, theses results are not definitive, therefore the risk of cancer due to occupational exposure to DBCP remains a continuing concern. There are indications from in vitro experiments that mutagenic effects may occur also, but there has been no study yet of this possibility with mammalian subjects. Employees should be told of these possible effects and informed that some 20-25 years of experience in the manufacture and formulation of DBCP has not yet called such effects in employees of the pesticide industry to the notice of physicians and epidemiologists. A more detailed review of the known health effects are given in Enclosure 1.
Keywords
Occupational-exposure; Concentration-level; Respirators; Personal-protective-equipment; Occupational-safety-programs; NIOSH-Criteria-Document
CAS No.
96-12-8
Publication Date
19780101
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1978
NTIS Accession No.
PB81-228728
NTIS Price
A03
Identifying No.
(NIOSH) 78-115
NIOSH Division
DCDSD
Source Name
National Institute for Occupational Safety and Health
State
MD
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