The possible effects on the health of employees chronically exposed to DBCP may include sterility, diminished renal function, and degeneration and cirrhosis of the liver. In addition, ingestion of daily doses of DBCP by mice and rats has been found to result in the appearance of gastric cancers in both sexes of both species and in mammary cancers in female rats. Although an increased risk for cancer has not been seen with inhalation exposures, theses results are not definitive, therefore the risk of cancer due to occupational exposure to DBCP remains a continuing concern. There are indications from in vitro experiments that mutagenic effects may occur also, but there has been no study yet of this possibility with mammalian subjects. Employees should be told of these possible effects and informed that some 20-25 years of experience in the manufacture and formulation of DBCP has not yet called such effects in employees of the pesticide industry to the notice of physicians and epidemiologists. A more detailed review of the known health effects are given in Enclosure 1.