Current intelligence bulletin 51 - carcinogenic effects of exposure to propylene oxide.
NIOSH 1989 Jul; :1-14
Studies in animals have demonstrated that propylene oxide is a direct-acting carcinogen. B6C3F1 mice exposed by inhalation to propylene oxide developed hemangiomas and hemangiosarcomas of the nasal mucosa. F344/N rats exposed to propylene oxide in air developed papillary adenomas of the nasal epithelium. Degeneration of the olfactory epithelium and hyperplasia of the respiratory epithelium were induced in the nasal cavities of Wistar rats exposed to propylene oxide by inhalation. Squamous cell carcinomas of the forestomach developed in rats administered propylene oxide by gavage. Although epidemiologic data are not available from workers exposed to propylene oxide, the findings of cancer and other tumors in both rats and mice treated with propylene oxide meet the criteria established in the Occupational Safety and Health Administration Cancer Policy [Title 29 of the Code of Federal Regulations, Section 1990.112] for regarding propylene oxide as a potential occupational carcinogen. The National Institute for Occupational Safety and Health therefore recommends that occupational exposures to propylene oxide be reduced to the lowest feasible concentration. The purpose of the bulletin is to disseminate recent information on the potential carcinogenicity of propylene oxide. Recent studies of the chronic effects of the chemical in animals have produced evidence that cancer is associated with exposure to propylene oxide. The bulletin describes the results of those animal studies, presents the known human health effects of propylene oxide, and suggests guidelines for minimizing occupational exposures.
Exposure-levels; Hazardous-materials; Malignant-neoplasms; Protective-clothing; Laboratory-animals; Humans
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
(NIOSH) 89-111; CIB 51
National Institute for Occupational Safety and Health