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Current intelligence bulletin 46 - methylene chloride.

Authors
NIOSH
Source
NIOSH 1986 Apr; :1-18
NIOSHTIC No.
20000243
Abstract
B6C3F1 mice exposed to methylene chloride in air developed cancers (alveolar/bronchiolar carcinomas) and tumors (alveolar/bronchiolar adenomas) of the lung, and cancers (hepatocellular carcinomas) of the liver. Fischer 344/N rats exposed to methylene chloride in air developed tumors (fibromas and fibroadenomas) of the mammary gland. Sprague-Dawley rats exposed to methylene chloride in air developed cancers (sarcomas) of the salivary glands and tumors (fibromas and fibroadenomas) of the mammary glands. Though existing epidemiologic data derived from workers exposed to methylene chloride are inconclusive, the observation of cancers and tumors in both rats and mice treated with methylene chloride meets the criteria established in the Occupational Safety and Health Administration (OSHA) Cancer Policy for considering methylene chloride a "potential occupational carcinogen." Therefore, the National Institute for Occupational Safety and Health (NIOSH) recommends that worker exposure to methylene chloride be controlled to the lowest feasible limit.
Keywords
Cancer; Carcinogens; Carcinomas; Neoplasms; Tumors; Animal-studies; Epidemiology
Publication Date
19860418
Document Type
Numbered Publication; Current Intelligence Bulletin
Fiscal Year
1986
NTIS Accession No.
PB86-208303
NTIS Price
A03
Identifying No.
(NIOSH) 86-114; CIB 46
NIOSH Division
DSDTT
Source Name
National Institute for Occupational Safety and Health
State
OH
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