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The Chemical Properties of Silica Particle Surface in Relation to Silica-cell Interactions.

Authors
Shi-X; Dalal-NS; Hu-XN; Vallyathan-V
Source
J Toxicol and Environ Health 1989 27:435-454
Link
NIOSHTIC No.
10007687
Abstract
Although silicosis has been studied extensively, the mechanism is still not fully understood. Experiments do provide evidence that the actions of unique properties of silica surface on the cell membrane are the starting point of silicotic processes. This paper summarizes literature on chemical properties of silica surface and the effect of particle size on silica toxicity. This paper also discusses the ways in which silica dusts are thought to interact with the cell membrane, with emphasis on freshness, hydrogen bonding, and free-radical interactions.
Publication Date
19890101
Document Type
OP; Final Contract Report;
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
MIR 3-90
NIOSH Division
WO;
Source Name
J. Toxicol. and Environ. Health, V. 27, 1989, PP. 435-454
State
WV;
Performing Organization
West Virginia University
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