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Characterization of alveolar macrophage eicosanoid.

Authors
Kuhn-DC; Griffith-JW; Stauffer-JL; Riling-S; Demers-LM
Source
Prostaglandins 1993 Sep; 46(3):207-220
NIOSHTIC No.
10004809
Abstract
The relative activation of eicosanoid production which results from the exposure of the alveolar macrophage (AM) to mineral dusts is thought to be a key factor in the pathophysiology of occupational lung disease. We compared in vitro basal and silica-stimulated production of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) by AM from normal humans and non-human primates (Macaca nemestrina). In addition, we instilled mineral dusts directly into one lung of the non-human primate and evaluated AM eicosanoid production at two week intervals following dust instillation. Unstimulated AM from humans produce more PGE2 and TXA2 than do AM from M. nemestrina. However, in vitro exposure of AM from both species to silica dust produced a qualitatively similar increase in TXA2 production accompanied by no change in PGE2 production. Sequential analysis of AM eicosanoid production following a single bolus exposure to bituminous or anthracite coal dusts, titanium dioxide (TiO2) dust or crystalline silica showed marked variability among individual non-human primates in qualitative and quantitative aspects of dust-induced eicosanoid production. However, the rank order of potency of the different dusts (silica > anthracite > bituminous) correlated with epidemiological evidence relating the type of dust mined to the incidence of pneumoconiosis. These studies suggest that the non-human primate may serve as a model for the study of both the role of eicosanoids in the etiology of dust-induced occupational lung disease and the biochemical basis for individual variability in the response of lung cells to mineral dust exposure.
Keywords
Quartz-dust; Silica-dusts; Mineral-dusts; Respiratory-system-disorders; Coal-dust; Laboratory-animals; Animal-studies
CODEN
PRGLBA
CAS No.
14808-60-7; 54397-85-2; 7631-86-9
Publication Date
19930901
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Identifying No.
MIR 13-94; Grant-Number-1105142
Issue of Publication
3
ISSN
0090-6980
Source Name
Prostaglandins
State
PA
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