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Biological Monitoring of Methanol Exposure, Final Performance Report, October 17, 1996.

Authors
Franzblau-A
Source
Department of Environmental and Industrial Health, School of Public Health, University of Michigan 1996 Oct:5 pages
Link
NIOSHTIC No.
00241066
Abstract
Reproducible and noninvasive methods for biologically monitoring occupational methanol (67561) exposures were developed, and the impact of exercise and cutaneous methanol exposures on such indices was evaluated. Formic-acid (64186) in urine was used as a quantitative biological exposure indicator for exposure of humans to methanol via the inhalation route and via the cutaneous route. Methanol in urine was evaluated as a quantitative biological exposure indicator for human exposures to methanol. The use of methanol in end expired air was evaluated as a quantitative biological exposure indicator. The effects of exercise, monitored by the ventilation rate, on formic-acid in urine, methanol in urine and methanol in end expired air were evaluated in humans exposed to methanol via the inhalation route. Formic-acid was a very poor biological indicator of methanol exposure in the range of the permissible exposure and threshold limit values. Regarding the use of methanol in urine as a biological index indicated that all methanol based parameters were approximately linearly related to exposure concentrations, but there was considerable inter-individual variations in all measured parameters. Blood and breath concentrations of methanol were disproportional for varying periods of time during and following cessation of methanol exposure, depending on the route of exposure. In settings where both dermal and inhalation exposures can occur, it would be necessary to wait at least 2 hours to collect breath specimens following cessation of methanol exposure.
Keywords
NIOSH-Grant; Grants-other; Biological-monitoring; Alcohols; Inhalation-studies; Skin-exposure; Skin-absorption; Urinalysis;
Contact
Environmental & Indust Health University of Michigan 1420 Washington Heights Ann Arbor, MI 48109-2029
CAS No.
67-56-1; 64-18-6;
Publication Date
19961017
Document Type
Final Grant Report;
Funding Amount
363589.00
Funding Type
Grant;
Fiscal Year
1997
NTIS Accession No.
PB98-137755
NTIS Price
A01
Identifying No.
Grant-Number-R01-OH-03024
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other;
Source Name
Department of Environmental and Industrial Health, School of Public Health, University of Michigan
State
MI;
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
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