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Chronic interstitial lung disease in nylon flocking industry workers - Rhode Island, 1992-1996.

Authors
Kern-DG; Durand-KT; Crausman-RS; Neyer-A; Kuhn-C III; Vanderslice-RR; Lougheed-MD; O'Donnell-DE; Munt-PW
Source
MMWR 1997 Sep; 46(38):897-901
NIOSHTIC No.
00240942
Abstract
Preliminary findings were reported for an investigation in Rhode Island of an outbreak of interstitial lung disease (ILD) among workers involved in the manufacture of finely cut nylon (flock) and flocked fabric. In November of 1994, a 35 year old textile worker presented for evaluation of chronic ILD. To identify additional ILD cases among the 127 current production workers at the facility, all employees with persistent respiratory symptoms were encouraged to undergo full pulmonary function testing, chest radiography, and high resolution computerized chest tomography (HRCT). Transbronchial or wedge biopsy was performed for those with unexplained restrictive lung function, impaired diffusing capacity or HRCT findings consistent with ILD. The study cohort, 165 persons, also included some former workers. Seven of the cohort were identified with flock worker's lung. Their mean age was 41 years. Two were current smokers, four had discontinued smoking more than 18 months earlier, one had never smoked. The median latencies from time of hire to onset of symptoms and from onset of symptoms to time of diagnosis were 6 years and 1 year, respectively. Tissues obtained demonstrate nonspecific interstitial pneumonia in five patients and bronchiolitis obliterans organizing pneumonia in the sixth. All had nodular lymphoid infiltrates, four had germinal centers. Preliminary air sampling at the facility revealed extremely high short term total dust concentrations up to 83mg/m3, only modest concentrations of fungal spores and endotoxin, low levels of volatile organic compounds, and negligible concentrations of metals.
Keywords
NIOSH-Author; NIOSH-Publication; Lung-irritants; Epidemiology; Respiratory-system-disorders; Textiles-industry; Textile-workers; Air-quality-monitoring; Lung-disease; Risk-factors
CODEN
MMWRB6
Publication Date
19970926
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
38
ISSN
0892-3787
NIOSH Division
DRDS
Priority Area
Respiratory-system-disorders
Source Name
Morbidity and Mortality Weekly Report
State
RI
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