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Time-related factors in radiation-sancer dose response.

Authors
Wing-SB; Richardson-DB
Source
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1997 Aug; :1-229
Link
NIOSHTIC No.
00240645
Abstract
The effects of low level, external exposure to ionizing radiation on the mortality of workers at Oak Ridge National Laboratory (ORNL) were investigated. The retrospective cohort study included 14,095 ORNL workers hired between 1943 and 1972 and followed through 1990. The focus on the analysis was on time related factors which influenced the association between all cancer mortality rates and cumulative external radiation dose. The data indicated that the cumulative dose received after age 45 strongly predicted all cancer mortality among these workers under a range of lag assumptions, and provided estimates of similar magnitude for lung cancer mortality and mortality from cancers other than lung. The cumulative dose received at older ages was more strongly associated with subsequent cancer mortality than lifetime cumulative dose. The strong evidence of a dose response relationship and the substantial magnitude of this association suggest that by considering age at exposure a smaller, more relevant time period of exposure can be identified. The authors suggest that if the effects of low level radiation do indeed increase with age, then differences in radiosensitivity need to be incorporated into considerations of radiation protection, medical uses of radiation, and the implications of industrial and military applications of nuclear technologies.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Lung-cancer; Humans; Radiation-exposure; Cancer-rates; Epidemiology; Age-factors; Risk-analysis; Nuclear-radiation; Ionizing-radiation; Occupational-exposure
Contact
Epidemiology University of North Carolina Cb#7400 Mcgavran-Greenberg HAl Chapel Hill, NC 27599-7400
Publication Date
19970805
Document Type
Final Grant Report
Funding Amount
63968
Funding Type
Grant
Fiscal Year
1997
NTIS Accession No.
PB98-130925
NTIS Price
A12
Identifying No.
Grant-Number-R03-OH-03343
NIOSH Division
OEP
Source Name
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
State
NC
Performing Organization
University of North Carolina Chapel Hill, Chapel Hill, North Carolina
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