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Enhanced pulmonary inflammatory response to ozone during lactation in rats: evaluation of the influence of inhaled dose.

Authors
Weideman-PA; Chen-LC; Gunnison-AF
Source
Inhal Toxicol 1996 Jul; 8(5):495-519
NIOSHTIC No.
00239329
Abstract
The influence of inhaled dose on the pulmonary inflammatory response to ozone (10028156) in lactating rats was investigated. Groups of lactating and postlactating Sprague-Dawley-rats were exposed either to filtered air or to nominal ozone concentrations of 0.3, 0.5 or 1.0 part per million (ppm) for 6 hours. Lactating rats were exposed on day 13 postpartum. Postlactating rats were exposed on day 13 postpartum, 10 days after pups were removed. Ventilation was measured during ozone exposure using barometric plethysmography. In response to increased metabolic demand, the minute volume of air breathing in postpartum rats on day 13 of lactation increased to about 150% of that of age matched post lactating rats with the same lung size. This resulted in greater inhaled ozone doses in lactating rats compared to postlactating rats identically exposed. The authors conclude that these findings confirm earlier reports of enhanced pulmonary inflammation in lactating rats compared to postlactating rats following exposure to these concentrations of ozone. A significant portion, but not all, of this enhanced response can be accounted for by the greater ventilation of lactating rats compared to postlactating rats, which results in a greater inhaled dose of ozone at equivalent atmospheric concentrations.
Keywords
NIOSH-Publication; NIOSH-Grant; Training; Laboratory-animals; Toxic-gases; Lung-irritants; Pollutants; Respiratory-system-disorders; Pulmonary-function; Reproductive-effects
Contact
Community Medicine Mount Sinai School of Medicine One Gustave L Levy Place Bx108 New York, NY 10029
CODEN
INHTE5
CAS No.
10028-15-6
Publication Date
19960701
Document Type
Journal Article
Funding Amount
2315138
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-07125
Issue of Publication
5
ISSN
0895-8378
Priority Area
Respiratory-system-disorders
Source Name
Inhalation Toxicology
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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