Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Studies on the mutagenicity of mild gasification products of coal and their subfractions by the salmonella/microsomal assay.

Authors
Zhong-Z; Stamm-SC; Robbins-S; Bryant-D; Lan-W; Xin-F; Ma-JK; Whong-Z; Ong-M
Source
Environ Res 1997 Jan; 72(1):32-44
NIOSHTIC No.
00238854
Abstract
A study was conducted examining the mutagenic effects of coal derived mild gasification products. Six gasification products derived from different coal sources and processing conditions were tested using the Ames Salmonella/microsomal assay following dissolution in dimethyl-sulfoxide (DMSO) or polyoxyethylene-sorbitan- monooleate (Tween-80). Previous analyses conducted on seven other gasification products demonstrated the importance of using at least two different solvents. In those analyses, one of the products was mutagenic using both solvents and one was mutagenic only using Tween- 80. In the current study each of the six samples tested positive in at least one analysis using DMSO or Tween-80, strains (TA-98) or (TA- 100), and with or without metabolic activation by S9 mix. Analysis of the mutagenic activity of basic, acidic, nonpolar, and polar neutral subfractions of five of the mutagenic and two of the nonmutagenic samples demonstrated that at least the nonpolar neutral fraction had mutagenic activity. The mutagenic activities of particular subfractions were attributed to their high concentrations of aromatic amines and other substituted aromatic hydrocarbons. This hypothesis was supported by the results of an experiment examining the relationship between the hydrogen/carbon ratio of the subfractions and their mutagenic effects.
Keywords
NIOSH-Author; Mutagenicity; Coal-gasification; Aromatic-hydrocarbons; Chemical-composition; Genotoxic-effects; In-vitro-study
CODEN
ENVRAL
Publication Date
19970101
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0013-9351
NIOSH Division
DRDS
Source Name
Environmental Research
State
WV
TOP