Suppression of silica-induced toxicity with organosilane surface coating.
Castranova-V; Dyke-K; Wu-L; Dalal-NS; Vallyathan-V
Silica and Silica-Induced Lung Diseases. Castranova V, Vallyathan V, Wallace WE, eds., Boca Raton, FL: CRC Press, 1995 Dec; :283-291
The possibility of reducing the cytotoxicity of crystalline silica (14808607) through the use of an organosilane surface coating was considered. Theories which have been proposed to account for the cytotoxicity of crystalline silica were reviewed. In each of the theories discussed, surface properties were important in the cytotoxicity of silica. It was proposed that the application of an organosilane material to the surface of silica particles would decrease their ability to cause lung disease. In addition to preventing the cytotoxic effects of silica, organosilane coating also would effectively decrease the ability of silica particles to activate oxidant production by alveolar macrophages. Prosil-28, an organosilane commonly used to silicanize laboratory glassware, was used to coat silica, and the coated silica was used in in-vitro and in-vivo studies. Studies indicated that coated silica is significantly less inflammatory and fibrotic, as determined by measuring lung weight and hydroxyproline content, respectively. The authors suggest that further studies examine whether it is possible to incorporate organosilane coating agents into water sprays of drill bits or rock grinders, thus coating silica particles as they are generated, and determine if such treatment would decrease the pathogenic potential of silica dust.
Silica-dusts; Mineral-dusts; Respiratory-system-disorders; Lung-irritants; Alveolar-cells; In-vitro-studies; In-vivo-studies; Coatings; Protective-coatings
Book or book chapter
Castranova-V; Vallyathan-V; Wallace-WE
Silica and Silica-Induced Lung Diseases