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A vinyl chloride case-control study.

Authors
Steenland-K
Source
Case studies in occupational epidemiology. Steenland K, ed. New York: Oxford University Press, 1993 Jan; :66-75
Link
NIOSHTIC No.
00238244
Abstract
Investigators examined the reports of an earlier study of liver cancers occurring at a polyvinyl-chloride (9002862) (PVC) facility in Louisville, Kentucky to determine whether exposure could cause cancers at other sites, principally the lung and brain. This study was described as part of a text book and took the reader through the same steps that the investigator took when conducting the actual study to allow the student to solve the same problems that the investigator solved in the course of the study. A new cohort mortality study was conducted of all male workers at the site, not just those exposed to vinyl-chloride (75014) gas. The cohort was restricted to workers between 1942 and 1973 and had follow up through 1986. The study findings indicated that workers exposed to vinyl-chloride gas experienced a significant excess of liver cancer, particularly the rare angiosarcoma of the liver. This excess was related to the cumulative dose of vinyl-chloride gas. Other cancers suspected a-priori were not found to be associated with exposure to vinyl-chloride gas. Exposure to polyvinyl-chloride dust was not found to be related to either liver, lung, or brain cancer incidence.
Keywords
Cancer-rates; Liver-cancer; Lung-cancer; Respiratory-system-disorders; Risk-factors; Dust-exposure; Toxic-gases; Occupational-exposure; Epidemiology
CAS No.
9002-86-2; 75-01-4
Publication Date
19930101
Document Type
Book or book chapter
Editors
Steenland-K
Fiscal Year
1993
NTIS Accession No.
NTIS Price
ISBN No.
9780195068313
NIOSH Division
DSHEFS
Priority Area
Respiratory-system-disorders
Source Name
Case studies in occupational epidemiology
State
KY; NY; OH
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