Beckett-WS; Chen-LC; Cosma-G; Fine-J; Garte-S; Gordon-T; Kinney-P; Sparer-J
Occupational Medicine Program, Yale University, New Haven, Connecticut 1996 Jul:34 pages
The acute response to zinc-oxide (1314132) fumes in naive human subjects and galvanized sheet metal workers was investigated. Of 12 naive subjects, ten experienced a mild fever after a 2 hour exposure to zinc-oxide fume at 5mg/m3 (the OSHA permissible exposure limit) or 2.5mg/m3. Metal fume fever symptoms were significantly increased 6 and 9 hours after a 5mg/m3 exposure. The most common symptoms were fatigue, muscle ache, and cough. Elevated white blood cell counts were also seen. Those who experienced mild symptoms and fever developed tolerance of these effects with repeated exposures on subsequent days. Sheet metal workers with ongoing low level exposure showed tolerance to exposure at 5mg/m3. However, zinc- oxide exposure in these individuals induced elevated levels of interleukin-6 in the blood. The findings demonstrated that mild symptoms and fever can occur in previously unexposed men and women several hours after they breathe ultrafine zinc-oxide fumes for only 2 hours at the 5.0mg/m3 level. This occurred in a high proportion of healthy and normal individuals.
NIOSH-Grant; Pulmonary-system-disorders; Metal-fume-fever; Metalworking-industry; Metal-oxides; Respiratory-system-disorders; Nanotechnology
Occupational Medicine Yale Univ Sch of Med 333 Cedar St/cb 5039 New Haven, CT 06510
Final Grant Report
NTIS Accession No.
Occupational Medicine Program, Yale University, New Haven, Connecticut
Yale University, New Haven, Connecticut