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Metal fume fever.

Authors
Beckett-WS; Chen-LC; Cosma-G; Fine-J; Garte-S; Gordon-T; Kinney-P; Sparer-J
Source
Occupational Medicine Program, Yale University, New Haven, Connecticut 1996 Jul:34 pages
Link
NIOSHTIC No.
00238192
Abstract
The acute response to zinc-oxide (1314132) fumes in naive human subjects and galvanized sheet metal workers was investigated. Of 12 naive subjects, ten experienced a mild fever after a 2 hour exposure to zinc-oxide fume at 5mg/m3 (the OSHA permissible exposure limit) or 2.5mg/m3. Metal fume fever symptoms were significantly increased 6 and 9 hours after a 5mg/m3 exposure. The most common symptoms were fatigue, muscle ache, and cough. Elevated white blood cell counts were also seen. Those who experienced mild symptoms and fever developed tolerance of these effects with repeated exposures on subsequent days. Sheet metal workers with ongoing low level exposure showed tolerance to exposure at 5mg/m3. However, zinc- oxide exposure in these individuals induced elevated levels of interleukin-6 in the blood. The findings demonstrated that mild symptoms and fever can occur in previously unexposed men and women several hours after they breathe ultrafine zinc-oxide fumes for only 2 hours at the 5.0mg/m3 level. This occurred in a high proportion of healthy and normal individuals.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Metal-fume-fever; Metalworking-industry; Metal-oxides; Respiratory-system-disorders; Nanotechnology
Contact
Occupational Medicine Yale Univ Sch of Med 333 Cedar St/cb 5039 New Haven, CT 06510
CAS No.
1314-13-2
Publication Date
19960726
Document Type
Final Grant Report
Funding Amount
697800
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
PB97-206379
NTIS Price
A04
Identifying No.
Grant-Number-R01-OH-02987
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Occupational Medicine Program, Yale University, New Haven, Connecticut
State
CT
Performing Organization
Yale University, New Haven, Connecticut
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