Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Detecting lung overload by magnetometry.

Authors
Ferin-J; Morrow-PE; Oberdorster-G
Source
Department of Environmental Medicine, University of Rochester, Rochester, New York 1996 Jul; :1-27
Link
NIOSHTIC No.
00238187
Abstract
A magnetic test aerosol and a magnetometric system were developed for the measurement of dust clearance rates in rodents. Fischer-344 rats were exposed to micronized 1 to 5 micrometer diameter magnetite and micronized 250 micrometer diameter titanium-dioxide aerosols, alone or as a mixture. Magnetometry was performed using eight flux gate magnetometers in two arrays. A rat was placed in a restraint tube and exposed to a brief magnetization pulse; the tube was then moved between the arrays. The results indicated that the present geometric design gave reproducible measures of magnetite dust in the lungs of rats. At low lung burdens of magnetite the in-vivo method of magnetometry reflected the retention behavior of these particles reasonably well. At high lung burdens, the measured retention of magnetite may not accurately reflect the actual behavior of these particles. The relaxation rate of the magnetic signal of the retained particles may be useful as an indicator of the localization of the particles. The authors suggest that further development of the magnetometric method for noninvasive measurement of the pulmonary particle clearance function in humans should be based on a thorough analysis of the observed discrepancy in measured retention half times between low and high magnetite lung burdens.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Dust-inhalation; Laboratory-animals; Lung-burden; Inhalation-studies
Contact
Environmental Health Scis Ctr University of Rochester 601 Elmwood Ave, Box Ehsc Rochester, NY 14642
Publication Date
19960709
Document Type
Final Grant Report
Funding Amount
832522
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
PB97-206361
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-002772
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Department of Environmental Medicine, University of Rochester, Rochester, New York
State
NY
Performing Organization
University of Rochester, Rochester, New York
TOP