Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Role of fungal spores in ODTS.

Authors
Sorenson-WG; Shahan-TA; Milanowski-J; Lewis-DM
Source
Agricultural health and safety: workplace, environment, sustainability. McDuffie HH, Dosman JA, Semchuk KM, Olenchock SA, Senthilselvan A, eds. Boca Raton, FL: Lewis Publishers, 1995 Apr; :105-108
Link
NIOSHTIC No.
00237627
Abstract
The inflammatory potential of live spores that occurs during the interaction of the following fungi with alveolar macrophages (AMs) in-vitro was investigated. Pure cultures of Aspergillus-fumigatus, Aspergillus-niger, Aspergillus-terreus, and Penicillium-spinulosum were isolated from materials associated with outbreaks of organic dust toxic syndrome. In general, the response of rat AMs was little or weak, in the form of direct chemotactic responses to the diffusates, except for A-niger. Exposure of rat and guinea-pig AMs to live spores of all three Aspergillus species resulted in the release of a factor that stimulated a chemotactic response of human PMNs. Spores of P-spinulosum were unable to germinate at 37 degrees- C and stimulated little response. Rat and guinea-pig AMs both responded the most to A-terreus, and somewhat less to A-fumigatus and A-niger. A dose dependent release of LTB4 was noted when rat AMs were incubated in the presence of live spores from all four of the fungi. Short term exposure to live spores in the presence of PMA resulted in enhanced superoxide anion production if the spores were washed immediately prior to the study. Spore diffusates of A- niger and A-fumigatus caused a dose dependent decrease in superoxide anion production stimulated by PMA. The authors conclude that, because of the differences observed in fungi germination, diffusate chemotactic activity, and superoxide anion production, the fungi in this study might be treated differently in the lung, therefore eliciting differential responses.
Keywords
Dust-exposure; Microorganisms; Alveolar-cells; Lung-cells; Cell-cultures; Organic-dusts; Dose-response; In-vitro-study; Mycology; Mammalian-cells;
Publication Date
19950418
Document Type
Conference/Symposia Proceedings
Editors
McDuffie-HH; Dosman-JA; Semchuk-KM; Olenchock-SA; Senthilselvan-A
Fiscal Year
1995
NTIS Accession No.
NTIS Price
ISBN No.
9780873716178
NIOSH Division
DRDS
Source Name
Agricultural health and safety: workplace, environment, sustainability
State
WV
TOP