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Assessment of reproductive disorders and birth defects in communities near hazardous chemical sites. III. Guidelines for field studies of male reproductive disorders.

Authors
Wyrobek-AJ; Schrader-SM; Perreault-SD; Fenster-L; Huszar-G; Katz-DF; Osorio-AM; Sublet-V; Evenson-D
Source
Reprod Toxicol 1997 Mar; 11(2/3):243-259
NIOSHTIC No.
00236018
Abstract
A workgroup discussed the possible field investigation of a link between male reproductive disorders and environmental exposures. This report presented information regarding the male reproductive health effects of major concern, the prerequisite information needed before considering a field study with particular emphasis on exposures and the number of men who are exposed, selection of study designs, the utility of questionnaires, and the selection and prioritization of relevant biomarkers. Male reproductive health effects of major concern included male infertility, male neuroendocrine or sexual dysfunction, and male mediated effects on the pregnancy or offspring. Study designs discussed include case reports, surveillance systems or registries, cross sectional studies, and cohort or prospective studies. Methods for assessing male reproductive disorders include reproductive history, physical examination and general health, biomarkers of neuroendocrine status including sexual function and semen quality, biomarkers of sexual function, biomarkers of neuroendocrine function, biomarkers of semen analysis, sperm counts, sperm motility, sperm morphology, viability assays, and expertise in specific semen sampling.
Keywords
NIOSH-Author; Reproductive-system-disorders; Reproductive-hazards; Fertility; Spermatogenesis; Hormone-activity; Endocrine-system; Environmental-health-monitoring; Humans
CODEN
REPTED
Publication Date
19970301
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
2/3
ISSN
0890-6238
NIOSH Division
DBBS
Source Name
Reproductive Toxicology
State
CA; OH; NC; CT; SD
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