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Reduction of lung dust burden in pneumoconiosis by whole-lung lavage.

Authors
Wilt-JL; Banks-DE; Weissman-DN; Parker-JE; Vallyathan-V; Castranova-V; Dedhia-HV; Stulken-E; Ma-JK; Ma-JY; Cruzzavala-J; Shumaker-J; Childress-CP; Lapp-NL
Source
J Occup Environ Med 1996 Jun; 38(6):619-624
NIOSHTIC No.
00235796
Abstract
The use of whole lung lavage to reduce lung dust burden in two miners with moderately advanced simple pneumoconiosis was described. The patients, a 54 year old man who had worked as an underground roof bolter and motorman, and a 55 year old driller at a surface coal mine, demonstrated normal lung function and chest radiographs showing ILO profusion category 2 nodular interstitial changes. Whole lung lavage with agitation by transmitted pressure from an anesthesia bag was performed on both patients. One patient suffered a hydropneumothorax during the whole lung lavage procedure; the technique was thus modified to better monitor and limit peak airway pressures. Whole lung lavage removed a considerable amount of mineral dust as well as proinflammatory cytokines, macrophages, growth factors, and cellular enzymes. Amounts of mineral dust recovered ranged from 0.40 gram in the right lung of one patient to 1.82 grams in the right lung of the other patient. The authors conclude that long term follow up is needed to provide information regarding the importance of removing mineral dust and inflammatory cells from the lungs of individuals with progressive dust induced pulmonary disease.
Keywords
NIOSH-Publication; NIOSH-Author; NIOSH-Cooperative-Agreement; Pulmonary-system-disorders; Occupational-medicine; Lung-burden; Lung-disorders; Medical-treatment; Mineral-dusts; Coal-miners; Coal-workers-pneumoconiosis; Humans
CODEN
JOEMFM
Publication Date
19960601
Document Type
Journal Article
Funding Amount
2937066
Funding Type
Cooperative Agreement
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U60-CCU-306149
Issue of Publication
6
ISSN
1076-2752
Priority Area
Pulmonary-system-disorders
Source Name
Journal of Occupational and Environmental Medicine
State
DC
Performing Organization
Center to Protect Workers' Rights
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