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The Relationship of vitamin B6 status to median nerve function and carpal tunnel syndrome among active industrial workers.

Authors
Franzblau-A; Rock-CL; Werner-RA; Albers-JW; Kelley-MP; Johnston-EC
Source
J Occup Environ Med 1996 May; 38(5):485-491
NIOSHTIC No.
00235782
Abstract
The relationship of vitamin-B6 status to median nerve function and carpal tunnel syndrome was examined in active industrial workers. In order to address potential weaknesses in previously reported studies, this study incorporated a large number of randomly selected subjects, standardized electrophysiologic assessment of nerve function, and multiple complementary measurements of vitamin-B6 status. The study group was composed of 125 randomly selected active workers (67% females) from two industrial facilities. The workers completed a self administered symptoms questionnaire and underwent electrodiagnostic testing of the median and ulnar sensory nerves. Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. Vitamin-B6 status was normal in most subjects; an abnormal EGPT index was found in only ten workers. Median mononeuropathy was detected in 31 participants. Vitamin-B6 status was not related to self reported symptoms associated with carpal tunnel syndrome or electrophysiologically determined median or ulnar nerve function. The authors conclude that the findings do not support a relationship between carpal tunnel syndrome among active industrial workers and vitamin-B6 status; the routine prescription of vitamin-B6 to patients with carpal tunnel syndrome should therefore be reconsidered.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Occupational-medicine; Humans; Carpal-tunnel-syndrome; Cumulative-trauma-disorders; Vitamins; Nerve-function; Dietary-effects; Electrophysiological-measurements; Musculoskeletal-system-disorders; Musculoskeletal-system; Repetitive-work; Cumulative-trauma; Carpal-tunnel-syndrome; Hand-injuries; Vitamins; Age-factors; Ergonomics
Contact
Environmental & Indust Health the University of Michigan 1420 Washington Heights Ann Arbor, MI 48109-2029
CODEN
JOEMFM
Publication Date
19960501
Document Type
Journal Article
Funding Amount
610264
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02941
Issue of Publication
5
ISSN
1076-2752
Priority Area
Grants Other
Source Name
Journal of Occupational and Environmental Medicine
State
MI
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
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