Lung disease in Chinese textile workers.
Department of Environmental Health, School of Public Health, Harvard University, Boston, Massachusetts 1995 Oct; :1-21
The relationship between long term exposure to cotton dust and associated gram negative bacterial endotoxin on lung function was investigated in an 11 year prospective study of cotton textile workers in Shanghai, China. Workers at a nearby silk thread manufacturing mill served as a referent population. The cotton workers had a larger loss of lung function as measured by forced expiratory volume in 1 second (FEV1) during the first 5 years of the study than in the second 6 years. The average decline among silk workers was slightly higher in the first period, but was more consistent. Cumulative dust but not endotoxin was associated with an 11 year loss of FEV1 after adjustment for appropriate confounders when cumulative exposure to dust and endotoxin were estimated and retired workers included in the testing. No evidence was found for interaction between smoking and cumulative dust or cumulative endotoxin exposure in these models. Results suggest that the cotton dust is a relatively potent cause of chronic airflow limitation independent of associated endotoxins.
NIOSH-Grant; Pulmonary-system-disorders; Textiles-industry; Cotton-dust; Cotton-mill-workers; Plant-dusts; Dust-exposure; Pulmonary-function; Occupational-exposure
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Department of Environmental Health, School of Public Health, Harvard University, Boston, Massachusetts