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Notice to readers update: provisional Public Health Service recommendations for chemoprophylaxis after occupational exposure to HIV.

Authors
NIOSH
Source
MMWR 1996 Jun; 45(22):468-472
NIOSHTIC No.
00234986
Abstract
Based on information suggesting that zidovudine (30516871) (ZDV) may be useful as postexposure prophylaxis (PEP) to reduce the risk of human immunodeficiency virus (HIV) transmission following occupational exposure to HIV infected blood, previous Public Health Service recommendations on management of occupational exposure to HIV were updated. ZDV PEP has been credited with a 79% decrease in the risk for HIV seroconversion following percutaneous exposure to HIV infected blood in a case/control study among health care workers. In the doses currently recommended, ZDV PEP usually is tolerated well by health care workers with short term toxicity primarily including gastrointestinal symptoms, fatigue, and headache. ZDV use in the second and third trimesters of pregnancy and early infancy has not been associated with serious adverse effects in mothers or infants. The use of ZDV chemoprophylaxis should be recommended for exposed workers after occupational exposure associated with the highest risk for HIV transmission. PEP should be initiated promptly, preferably within 1 to 2 hours of exposure. If the source patient or the patient's HIV status is not known, initiating PEP should be decided on a case by case basis.
Keywords
NIOSH-Author; Infectious-diseases; Disease-transmission; Disease-prevention; Health-care-personnel; Preventive-medicine; Occupational-exposure; Medical-treatment; AIDS-virus; Viral-infections; Occupational-medicine
CODEN
MMWRB6
CAS No.
30516-87-1
Publication Date
19960607
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
22
ISSN
0892-3787
Priority Area
AIDS-virus
Source Name
Morbidity and Mortality Weekly Report
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