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Review of experimental male-mediated behavioral and neurochemical disorders.

Authors
Nelson-BK; Moorman-WJ; Schrader-SM
Source
Neurotoxicol Teratol 1996 Nov; 18(6):611-616
NIOSHTIC No.
00234982
Abstract
The effects of paternal exposure to exogenous agents on offspring behavior or neurochemical alterations in experimental animals were reviewed. The agents reviewed in this report included age, alcohols, cyclophosphamide (50180), ethylene-dibromide (106934), lead (7439921), opiates, cocaine (50362), ethyl-methanesulfonate (62500), mitomycin-C (50077), and procarbazine (671169). Most of the studies of ethyl-alcohol (64175) indicated that paternal exposure produced hyperactivity in the offspring. Several studies have implicated exposure to cyclophosphamide with neurobehavioral deficits in children. Studies with ethylene-dibromide were suggestive of effects in offspring following paternal exposures, but there was only one laboratory which had investigated this finding. The authors suggest that additional replicatable studies be performed. Lead induced changes in early gene expression in early embryos, as well as alterations in hippocampal development of late fetal and early neonatal rats have been reported. Water maze performance of mice was adversely affected by the paternal exposures to opiates. Cocaine exposure to adult male Long-Evans-rats produced offspring with hyperactivity and a decreased capacity for avoidance learning.
Keywords
Laboratory-animals; Lead-poisoning; Reproductive-hazards; Nervous-system-disorders; Neuropathology; Developmental-disorders; Prenatal-exposure
CODEN
NETEEC
CAS No.
50-18-0; 106-93-4; 7439-92-1; 50-36-2; 62-50-0; 50-07-7; 671-16-9; 64-17-5
Publication Date
19961101
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0892-0362
NIOSH Division
DBBS
Source Name
Neurotoxicology and Teratology
State
OH
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