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Biomarkers to detect radiation exposures.

Authors
Kelsey-KT; Wiencke-JK; Liber-HL
Source
Biomarkers and Occupational Health: Progress and Perspectives. Mendelsohn ML; Peeters JP; Normandy MJ, eds., Washington, DC: Joseph Henry Press, 1995 Jan; :215-225
Link
NIOSHTIC No.
00234601
Abstract
The detection of radiation exposure using biological markers among exposed workers was discussed, with the focus on worker health monitoring. Several assays which were effective in detecting worker exposure were discussed which involved nonspecific lymphocyte, cytogenetic, or genetic mutation analyses. Of particular interest was the development of molecular biomarkers with the capability of distinguishing exposure between ionizing radiation and specific toxic chemicals. Current approaches to the development of biological markers were discussed, including those which could detect specific mutational events. Previous studies demonstrating specific chromosomal abnormalities corresponding to histological subtypes of leukemias or other human cancers were described. The use of mutational spectra in biomarker development was also discussed. Base pair substitutions, insertions, deletions, and larger chromosomal changes may be included in mutational spectra. The use of HPRT mutants in the detection of radiation signature lesions was emphasized and described in detail. The authors conclude that such biomarkers can be used in the detection of radiation specific exposure.
Keywords
NIOSH-Grant; Grants-other; Biological-monitoring; Occupational-exposure; Radiation-exposure; Ionizing-radiation; Chromosome-damage; Occupational-medicine
Contact
Environmental Health Harvard School of Public Hlth 665 Huntington Avenue Boston, MA 02115
Publication Date
19950101
Document Type
Book or book chapter
Editors
Mendelsohn-ML; Peeters-JP; Normandy-MJ
Funding Amount
162000
Funding Type
Grant
Fiscal Year
1995
NTIS Accession No.
NTIS Price
ISBN No.
0309051878
Identifying No.
Grant-Number-K01-OH-00110
Priority Area
Cancer
Source Name
Biomarkers and Occupational Health: Progress and Perspectives
State
WA; MA
Performing Organization
Harvard University, Boston, Massachusetts
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