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2-Ethoxyethanol and 2-methoxyethanol - developmental toxicity in Drosophila.

Authors
Lynch-D; Toraason-M
Source
Occup Hyg 1996 Jan; 2(1-6):171-174
Link
NIOSHTIC No.
00234201
Abstract
To further evaluate the usefulness of the Drosophila bioassay, a study was conducted to investigate how fruit-flies respond to treatment with 2-ethoxyethanol (110805) (2EE) and 2-methoxyethanol (109864) (2ME). 2EE and 2ME were dissolved in distilled water and mixed with Drosophila medium prior to use. Exposures were continuous from the egg through the third instar larvae. Treatment with 2EE resulted in a statistically significant increase in the incidence of wing blade notches in exposed flies at all exposure concentrations. A statistically significant increase in the incidence of bent humeral bristle defects was observed in flies exposed to all concentrations of 2ME. The authors suggest that these findings indicate that the Drosophila bioassay can be used to accurately identify glycol ethers with known developmental toxicity. These findings also suggest that this assay could serve as a prescreen for assessing the developmental toxicity of other glycol ethers not yet evaluated. Use of this prescreen could serve to prioritize chemicals for developmental toxicity evaluations in mammals.
Keywords
NIOSH-Author; Organic-solvents; Bioassays; Insects; Glycols; Reproductive-hazards; In-vivo-study; Developmental-disorders
CODEN
OCHYE9
CAS No.
110-80-5; 109-86-4
Publication Date
19960101
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
1-6
ISSN
1061-0251
NIOSH Division
DBBS
Source Name
Occupational Hygiene
State
OH
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