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General techniques for assessing male reproductive potential in human field studies.

Authors
Schrader-SM
Source
Methods in Toxicology, Vol. 3, Part A, Male Reproductive Toxicology. Chapin RE, Heindel JJ, eds. San Diego, CA: Academic Press, 1993 Jul; 3:362-371
Link
NIOSHTIC No.
00233246
Abstract
The general method for conducting field human studies to evaluate male fecundity was described. Before the field study, potential reproductive toxicants and potential populations to be studied must be identified. Once identified, potential populations should be evaluated for actual exposures, exposure histories, other potential toxicant exposures, and the climate of cooperation. A suitable comparison population must also be selected, taking into account factors such as temperature, geographic location, and socioeconomic status. The roles of the field study team (epidemiologist, physician, industrial hygienist, andrologist) during and after the field study were described. Semen analysis after the field trial should include morphological and morphometric analyses of sperm cell slides and assessment of motility from videotape. Blood serum should be analyzed for reproductive hormones, including luteinizing hormone, follicle stimulating hormone, and total and free testosterone. All data should be subjected to statistical analysis. Notifying participants of their results, without causing undue alarm, is a moral obligation of the researcher. The author concludes that human field studies are lengthy and complex undertakings that combine extensive planning, rigorous data collection and analysis, and concern and compassion for participants.
Keywords
Humans; Spermatozoa; Spermatogenesis; Toxic-effects; Health-surveys; Toxic-materials; Epidemiology; Reproductive-system
Publication Date
19930701
Document Type
Book or book chapter
Editors
Chapin-RE; Heindel-JJ
Fiscal Year
1993
NTIS Accession No.
NTIS Price
ISBN No.
9780124612075
NIOSH Division
DBBS
Source Name
Methods in Toxicology, Vol. 3, Part A, Male Reproductive Toxicology
State
OH
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